Chemical sciences literature
Application note: Study the stability of pharmaceutical formulations with Raman microscopy
Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.
Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope
With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.
Application note: Transmission Raman for monitoring pharmaceuticals
Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis. Benefit from the incredible chemical specificity and sensitivity of inVia using a transmission Raman configuration.
Application note: Study emulsions using the inVia confocal Raman microscope
The Renishaw inVia confocal Raman microscope is the ideal system for the complete 2D and 3D chemical analysis of emulsions and colloids.
Application note: Analyse coatings with the inVia™ confocal Raman microscope
Chemically characterise your coatings with Renishaw’s inVia confocal Raman microscope. It is the ultimate system for studies ranging from fundamental research on the materials involved through to final product quality control and failure analysis.
StreamHR Rapide - nasal spray
Using a Renishaw inVia confocal Raman microscope and WiRE™ software to image a drop of nasal medication. The image build up is shown at true data collection speed using StreamHR Rapide.
We have also produced a range of application examples, including the following.
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Imaging detergent powder
Reveal information about powder mixtures with inVia and StreamLine imaging. In this example, single component domains and their distribution are quantified from a large powder area.
Imaging a pharmaceutical tablet
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, active pharmaceutical ingredient (API) domains and their distributions are quantified from an entire tablet section.
Imaging inhaler constituents
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, inhaler active pharmaceutical ingredients (API's) are identified and their relative locations compared.
Imaging coated nasal spray particles
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, nasal spray particles are identified, with the active pharmaceutical ingredient (API) being shown to coat the excipient carrier paritcle.
3D imaging a polymer laminate
Reveal information about multi-layered polymer films with inVia and 3D imaging.
Imaging Pirinase nasal spray
Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, API domains and their distribution are quantified from a Pirinase droplet.
Analysing LA modes in polyethyleneReveal low wavenumber Raman bands with inVia. Here, the longitudinal acoustic mode (LAM) of high density polyethylene is shown.
Analysing lattice modes in sulfur
Reveal low wavenumber Raman bands with inVia. Here, the lattice modes (LAM) of sulfur are observed.
Analysing rotational modes of gases
Reveal low wavenumber Raman bands with inVia. Here, the rotational modes of atmospheric air bands are observed.
Analysing the composition of Piriton in high definition
This case study reveals the composition of an entire tablet in high definition with inVia.
Low wavenumber Raman imaging
Low wavenumber Raman bands contain important chemical and structural information. Traditionally low wavenumber Raman bands are observed using spectrometers with triple diffraction gratings, which do not provide sufficient Raman throughput to make imaging feasible. Renishaw's range of Eclipse filters for inVia make imaging of low wavenumber Raman bands easy.
Quantifying the composition of a SINGULAIR® tablet in high definition
Improve the accuracy of quantifying active pharmaceutical ingredient (API) domain sizes and amounts using inVia's high definition StreamLine™ imaging. SINGULAIR® (generically known as montelukast sodium) is a medication used to improve symptoms of asthma and allergic rhinitis. In this example, the SINGULAIR® API domains are quantified and compared. Different spatial resolution images show the benefit of generating large, high definition data.
Confocal Raman imaging of yogurt
Raman imaging of yoghurt can provide information on its protein-lipid network, the packing order of lipids and hydration, without employing any stains.