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Chemical sciences literature

Downloads: chemical sciences (pharmaceuticals)

  • Brochure:  Solutions for pharmaceutical analysis Brochure: Solutions for pharmaceutical analysis

    Renishaw is a world leader in Raman spectroscopy instrumentation, with over 25 years’ experience supplying Raman systems to customers worldwide. We are a global company, with a worldwide network of scientists and engineers who are on-hand to provide you with expert product, applications and technical support. We understand the many challenges within pharmaceutical analysis and our flexible solutions have been designed with your needs in mind. Whether novice or expert, formulator or quality analyst, we have a system to meet your requirements.

  • Product note:  RA802 Pharmaceutical Analyser Product note: RA802 Pharmaceutical Analyser

    The RA802 Pharmaceutical Analyser is a compact benchtop Raman imaging system that redefines formulation analysis. It is easy to use, yet gives rich chemical information. Designed exclusively for the pharmaceutical industry, the RA802 rapidly obtains detailed information on the distribution of chemical species. With unique LiveTrack™ focus-tracking technology, it can efficiently analyse uneven, curved, or rough surfaces at incredible speeds and without any sample preparation.

  • Application note:  New methods for determining content uniformity of formulations Application note: New methods for determining content uniformity of formulations

    The uniformity of a drug product’s contents is a parameter that requires constant monitoring. It is important from a handling/processing standpoint, and it is of the utmost importance for patient safety to ensure that the correct dose is delivered every time.

  • Application note:  Study the stability of pharmaceutical formulations with Raman microscopy Application note: Study the stability of pharmaceutical formulations with Raman microscopy

    Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.

  • Application note:  Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope

    With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.

  • Application note:  Transmission Raman for monitoring pharmaceuticals Application note: Transmission Raman for monitoring pharmaceuticals

    Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis.

  • Application note:  Combined chemical and particle distribution analysis of pharmaceutical powders Application note: Combined chemical and particle distribution analysis of pharmaceutical powders

    When formulating pharmaceuticals, it is important to understand the chemical composition and morphologies of the ingredients, as these can lead to changes in product performance. For example, active ingredient co-localisation and particle adhesion can affect the efficacy of formulation. This application note details how to use a Renishaw Raman system to conduct this type of analysis.

  • Application note:  Using Raman spectroscopy to tackle polymorphism, an industry problem Application note: Using Raman spectroscopy to tackle polymorphism, an industry problem

    This note looks at incidences of polymorphism in drug development including advantages and challenges. It also examines a trial between manufacturers, where Renishaw’s Raman instruments were used by a leading pharmaceutical company in an attempt to prove infringement by a generic competitor.

  • Application note:  Raman imaging for deformulating a transdermal patch Application note: Raman imaging for deformulating a transdermal patch

    An application note detailing the RA802's ability to deformulate the make-up of a transdermal nicotine patch.

  • Application note:  Rapid polymorph identification with the RA802 Pharmaceutical Analyser Application note: Rapid polymorph identification with the RA802 Pharmaceutical Analyser

    The stability, bioavailability and processability of an active pharmaceutical ingredient (API) are key to a candidate molecule’s ability to be developed into a commercially viable product, sometimes referred to its ‘drugability’. Characterising the polymorphism of APIs has become an important consideration in this process.

  • White paper:  Finding fakes – using Raman imaging to identify counterfeit medicines White paper: Finding fakes – using Raman imaging to identify counterfeit medicines

    Identifying counterfeit drugs has become an area of increasing focus for regulatory authorities and also for pharmaceutical companies. Raman spectroscopy is highly specific and can differentiate between materials with similar chemical structures. This specificity makes Raman well-suited to identifying counterfeits which often use similar components to the reference product.

  • White paper:  Methods for deformulating drugs White paper: Methods for deformulating drugs

    In this white paper we look at reverse engineering existing drug products using Raman imaging. We show that the Renishaw RA802 Pharmaceutical Analyser can be used to successfully characterise innovator and generic products and facilitate deformulation activities, and can characterise the components, concentrations, particle sizes and distributions of the innovator formulation, allowing generic followers to adjust their processes in order to create equivalent products, or products which are strategically different.

Downloads: chemical sciences (polymers)

  • Application note:  Analysing microplastics with the inVia™ confocal Raman microscope Application note: Analysing microplastics with the inVia™ confocal Raman microscope

    Plastics are extensively used in products and packaging and, unfortunately, make their way into the environment, causing significant issues for wildlife. In addition to concerns about bulk plastic contamination, there has been much interest in microplastics. Raman spectroscopy, an optical scattering technique, has much to offer researchers investigating plastics, as it can identify them rapidly and non-destructively.

  • Application note:  Study polymers with the inVia confocal Raman microscope Application note: Study polymers with the inVia confocal Raman microscope

    The Renishaw inVia confocal Raman microscope is ideal for the 2D and 3D chemical analysis of polymers. Synthetic polymers display a broad range of properties and are extensively used in modern products. The study of polymers in terms of identification, spatial distribution and concentration is important as we search for novel materials, improve effectiveness of existing materials, and reduce the costs of products. The inVia microscope provides chemical specificity and sensitivity, in a non-destructive manner, with no sample manipulation and preparation required.

  • Technical note:  Using the inVia Raman microscope for locating and characterising microplastics Technical note: Using the inVia Raman microscope for locating and characterising microplastics

    Renishaw’s inVia confocal Raman microscope is ideally suited to the analysis of microplastics. A combination of optical and Raman imaging techniques with Renishaw's WiRE software are used to locate, image and characterise particles.

Downloads: chemical sciences (chemicals)

Movie

  • StreamHR Rapide - nasal spray

    Using a Renishaw inVia confocal Raman microscope and WiRE™ software to image a drop of nasal medication. The image build up is shown at true data collection speed using StreamHR Rapide.

Application examples

We have also produced a range of application examples, including the following.

If you would like to find out more, please contact your local representative using the button below, quoting the relevant document reference.

Document reference

Description
AS008

Imaging detergent powder

Reveal information about powder mixtures with inVia and StreamLine imaging. In this example, single component domains and their distribution are quantified from a large powder area.

AS009

Imaging a pharmaceutical tablet

Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, active pharmaceutical ingredient (API) domains and their distributions are quantified from an entire tablet section.

AS010

Imaging inhaler constituents

Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, inhaler active pharmaceutical ingredients (API's) are identified and their relative locations compared.

AS011

Imaging coated nasal spray particles

Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, nasal spray particles are identified, with the active pharmaceutical ingredient (API) being shown to coat the excipient carrier paritcle.

AS012

3D imaging a polymer laminate

Reveal information about multi-layered polymer films with inVia and 3D imaging.

AS015

Imaging Pirinase nasal spray

Reveal information about pharmaceutical formulations with inVia and StreamLine imaging. In this example, API domains and their distribution are quantified from a Pirinase droplet.

AS018

Analysing LA modes in polyethylene

Reveal low wavenumber Raman bands with inVia. Here, the longitudinal acoustic mode (LAM) of high density polyethylene is shown.
AS019

Analysing lattice modes in sulfur

Reveal low wavenumber Raman bands with inVia. Here, the lattice modes (LAM) of sulfur are observed.

AS020

Analysing rotational modes of gases

Reveal low wavenumber Raman bands with inVia. Here, the rotational modes of atmospheric air bands are observed.

AS022

Analysing the composition of Piriton in high definition

This case study reveals the composition of an entire tablet in high definition with inVia.

AS029

Low wavenumber Raman imaging

Low wavenumber Raman bands contain important chemical and structural information. Traditionally low wavenumber Raman bands are observed using spectrometers with triple diffraction gratings, which do not provide sufficient Raman throughput to make imaging feasible. Renishaw's range of Eclipse filters for inVia make imaging of low wavenumber Raman bands easy.

AS032

Quantifying the composition of a SINGULAIR® tablet in high definition

Improve the accuracy of quantifying active pharmaceutical ingredient (API) domain sizes and amounts using inVia's high definition StreamLine™ imaging. SINGULAIR® (generically known as montelukast sodium) is a medication used to improve symptoms of asthma and allergic rhinitis. In this example, the SINGULAIR® API domains are quantified and compared. Different spatial resolution images show the benefit of generating large, high definition data.

AS054

Confocal Raman imaging of yogurt

Raman imaging of yoghurt can provide information on its protein-lipid network, the packing order of lipids and hydration, without employing any stains.