Life sciences literature

The domain of biological research is shaped by our ability to peer into the world of the small. Simply seeing microscopic biological samples is useful, but by utilising Raman spectroscopy we can surpass sight into the molecular realm… and beyond! Download this brochure to discover the wealth of biological applications made possible by Renishaw's Raman systems.

Brochure: Biological analysis using Raman spectroscopy and imaging

The domain of biological research is shaped by our ability to peer into the world of the small. Simply seeing microscopic biological samples is useful, but by utilising Raman spectroscopy we can surpass sight into the molecular realm… and beyond! Download this brochure to discover the wealth of biological applications made possible by Renishaw's Raman systems.

[2.4MB]

Raman spectroscopy is sensitive to the presence of haem proteins and is ideal for studying their redox biology, without the need for isolation or staining. The redox of haem proteins is closely linked to their protein functions – oxygen transport and storage, electron transport, and scavenging of free radicals. By using Raman spectroscopy to elucidate redox states within biological systems, researchers can study redox dynamics and its effects on health regulation and diseases.

Application note: Redox biology with the inVia confocal Raman microscope

Raman spectroscopy is sensitive to the presence of haem proteins and is ideal for studying their redox biology, without the need for isolation or staining. The redox of haem proteins is closely linked to their protein functions – oxygen transport and storage, electron transport, and scavenging of free radicals. By using Raman spectroscopy to elucidate redox states within biological systems, researchers can study redox dynamics and its effects on health regulation and diseases.

[401kB]

Raman spectroscopy is an information-rich, label-free, non-invasive imaging technique that is ideal for life sciences research. It uses laser light scattering to provide a chemical fingerprint at each point of the analysed area and identifies the molecules present in samples.

Application note: Raman imaging for biological applications. No stains. No labels.

Raman spectroscopy is an information-rich, label-free, non-invasive imaging technique that is ideal for life sciences research. It uses laser light scattering to provide a chemical fingerprint at each point of the analysed area and identifies the molecules present in samples.

[509kB]

In a study conducted with the University of Oxford Neuropathology Department in the United Kingdom, we demonstrated discrimination between diseased and healthy brain tissue using the Renishaw Biological Analyser - RA816.

Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser

In a study conducted with the University of Oxford Neuropathology Department in the United Kingdom, we demonstrated discrimination between diseased and healthy brain tissue using the Renishaw Biological Analyser - RA816.

[384kB]

With Renishaw’s inVia confocal Raman microscope you can identify and characterise samples to provide chemical, spatial and structural information on multiple types of molecule, without labelling. It provides rich, detailed, chemical images and highly specific data at high spatial resolution, making it ideal for studying cells.

Application note: Cell imaging with the inVia confocal Raman microscope

With Renishaw’s inVia confocal Raman microscope you can identify and characterise samples to provide chemical, spatial and structural information on multiple types of molecule, without labelling. It provides rich, detailed, chemical images and highly specific data at high spatial resolution, making it ideal for studying cells.

[365kB]

Raman imaging is a powerful research tool for understanding the molecular composition, structure and distribution of different chemical species. Nano silver/gold colloids and roughened metallic substrates can be used to amplify the intensity of the Raman scattering of adsorbed molecules via SERS. This can increase the sensitivity and/or the specificity of the analysis. SERS imaging can be used to evaluate the efficacy of delivery of nanoparticles (NPs) into cells/animals. SERS measurement of labelled or surface-modified NPs can also be used for biosensing, multiplexing and theranostics.

Application note: Surface enhanced Raman spectroscopy (SERS) imaging using the inVia confocal Raman microscope

Raman imaging is a powerful research tool for understanding the molecular composition, structure and distribution of different chemical species. Nano silver/gold colloids and roughened metallic substrates can be used to amplify the intensity of the Raman scattering of adsorbed molecules via SERS. This can increase the sensitivity and/or the specificity of the analysis. SERS imaging can be used to evaluate the efficacy of delivery of nanoparticles (NPs) into cells/animals. SERS measurement of labelled or surface-modified NPs can also be used for biosensing, multiplexing and theranostics.

[333kB]

Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.

Application note: Raman imaging to reveal components and metabolites in wood cells and tissue

Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.

[266kB]

The December 2015 issue of 'The Pathologist' featured an article describing how Raman spectroscopy is a non-invasive way of obtaining morphological and chemical information about cells that may lead to better cancer research.

Portrait of a dying cell

The December 2015 issue of 'The Pathologist' featured an article describing how Raman spectroscopy is a non-invasive way of obtaining morphological and chemical information about cells that may lead to better cancer research.

[1.4MB]

Detecting the presence and depth of penetration of drug compounds in skin can prove challenging, current technologies fail to achieve adequate penetration through layers of dermal tissue. In this study, Raman spectroscopy using the Renishaw Biological Analyser - RA816 confirmed the presence of a topical compound in the epidermis and reticular dermis with high specificity and sensitivity.

Application note: Monitoring of transdermal drug delivery in skin using the Renishaw Biological Analyser

Detecting the presence and depth of penetration of drug compounds in skin can prove challenging, current technologies fail to achieve adequate penetration through layers of dermal tissue. In this study, Raman spectroscopy using the Renishaw Biological Analyser - RA816 confirmed the presence of a topical compound in the epidermis and reticular dermis with high specificity and sensitivity.

[705kB]

In a study conducted with the University of Oxford Neuropathology Department in the United Kingdom, we demonstrated discrimination between diseased and healthy brain tissue using the Renishaw Biological Analyser - RA816.

Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser

In a study conducted with the University of Oxford Neuropathology Department in the United Kingdom, we demonstrated discrimination between diseased and healthy brain tissue using the Renishaw Biological Analyser - RA816.

[384kB]

Raman tissue imaging is a unique method that can simultaneously describe the molecular composition and the distribution of multiple chemical species in tissues at a high spatial resolution, without labelling.

Application note: Tissue imaging with the inVia Raman microscope

Raman tissue imaging is a unique method that can simultaneously describe the molecular composition and the distribution of multiple chemical species in tissues at a high spatial resolution, without labelling.

[466kB]

Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.

Application note: Raman imaging to reveal components and metabolites in wood cells and tissue

Analysing Scots pine wood using the inVia™ confocal Raman microscope, to reveal high-resolution details of structure and chemical composition.

[266kB]