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RA816 Biological Analyser

An easy to use and compact benchtop Raman imaging system that redefines
tissue and biofluid analysis.

Designed exclusively for the biological community, the system rapidly obtains detailed information on the distribution and amount of biochemical species within biological samples including tissue biopsies, tissue sections and biofluids.

The RA816 Biological Analyser enables you to identify and assess biochemical changes associated with disease formation and progression. There is little to no sample preparation, and no contrast agents or tags are needed.

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RA816 Biological Raman Analyser


The RA816 Biological Analyser provides a practical solution for analysing biological samples. It is compact and transportable with optimised microscopic technology designed for biological and clinical sites.

  • Easy to use hardware and software
  • No need for stains or labels
  • Minimal to no sample preparation
  • Obtain full range of biochemical information (no need for prior knowledge of specific molecular targets)

For more detailed information, download the RA816 product note.


RA816 Biological Raman analyser

Powerful software

The RA816 Biological Analyser is entirely computer-controlled. Its software manages every step of the measurement process using pre-defined experiment setups. The unique macro image provides a comprehensive overview of all subsequent work and enables easy sample navigation and visualisation.

RA816 Biological Raman analyser and screen

High performance

Stable and repeatable analysis with integrated performance qualification and alignment. It features LiveTrack™ technology which enables you to track sample surface and retain focus on challenging samples and Streamline™ technology for high speed data collection and image generation.

RA816 Biological Raman analyser

Easy to use

The RA816 Biological Analyser is ideal for the clinical research environment and can acquire data unattended. Its queuing capability enables you to configure measurements and leave the instrument to run them; you can analyse multiple samples on a slide without the need for user intervention.


Raman image of brain tissue

Classification of brain glioma tumours

In a study conducted with the University of Oxford Neuropathology Department in the UK, we demonstrated discrimination between diseased and healthy brain tissue using the RA816 Biological Analyser. We were able to differentiate diseased and healthy tissues without the need for disease marker discovery and targeting.

Download the application note

Transdermal Raman image

Monitoring transdermal drug delivery

In a study, conducted with Miss Rubinder Basson from University of Manchester, Division of Musculoskeletal and Dermatological Sciences, the system used Empty modelling™ to demonstrate the presence and penetration depth of a compound in different skin tissue layers following application of a topical formulation.

Download application note

Medical research using
Raman Spectroscopy

The Renishaw Biological Analyser brings together the chemical analysis power of Raman spectroscopy (a light scattering technique) and advanced optical and spectroscopic imaging technologies in a simple, robust system. It produces outstanding results, quickly and easily. Watch the video to find out more.

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You can contact them by completing a form or sending an email.

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Downloads: RA816 Biological Analyser


Laser wavelength785 nm
Integral Renishaw high power near infrared diode laser, 300 mW at 785 nm, air cooled, with integral plasma filter. Laser power: > 150 mW at sample. Innovative StreamLine technology enables higher laser power use without sample damage
Spectral range100 cm-1 to 3250 cm-1
Performed in two separate scan ranges Range 1: 100 cm-1 to 2000 cm-1; Range 2: 1950 cm-1 to 3250 cm-1
Spectral dispersion2 cm-1 pixel-1
Data collection speedOver 1500 spectra/s
Minimum Raman image pixel size1 µm
Spatial resolution 1 µm per pixel
Objective8.2 mm working distance 0.55 NA 50× long working distance objective
Additional macro-view colour video camera
Field of viewMacro 21 mm × 16 mm
Micro 330 µm × 250 µm
Maximum tiled image sizeMacro 134 mm × 76 mm
High magnification 112 mm × 81 mm
White light modesWhite light transmission and reflection capability
FocusingMacro – Manual or pre-defined
Micro – Automatic (LiveTrack) or manual
Real time automated LiveTrack dynamic focusing for both Raman data acquisition and white light video viewing modes
System calibration and transferabilitySelf-calibration and auto-align using built in neon and silicon references
Automatic PQ data collection – (polystyrene)
Optional post measurement check (PMC) for inter-measurement validation
Maximum sample size~ (110 mm × 90 mm × 25 mm) – fits 96 well plate
Power, voltage100 – 240 VAC ± 10%, 50/60 Hz, 100 W maximum
Dimensions720 mm (W) × 502 mm (H) × 535 mm (D)
Mass (not including computer)54 kg
Laser classClass 1 laser product complies with IEC60825-1. CE marked